Lipidlowering Effects

Several mechanisms of action are considered responsible for this effect. The guggulsterones act as antagonists of the bile-acid receptor and of the farsenoid X receptor, which are involved in bile acid regulation and cholesterol metabolism. Crude guggul contains ion-exchange resins that may remove bile from the intrahepatic circulation (Urizar et al 2002, Wu et al 2002).

According to one review, eleven clinical studies have generally demonstrated that guggulipid from C. mukul significantly reduces triglyceride and total cholesterol levels; however, results from a recent double-blind randomised study were negative (Ulbricht et al 2005).

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