Although the mechanism of action is yet to be fully explained, studies show that chromium supplementation may decrease triglyceride levels, total and LDL-cholesterol and modestly increase HDL-cholesterol (Bahijri 2000, Lee & Reasner 1994, Press et al 1990, Preuss etal 2000).
Depression is often associated with insulin resistance, owing to Cortisol overproduction (McCarty 1994). The reputed antidepressant effects of chromium may be explained by improvements in insulin sensitivity (Davidson et al 2003) and related increases in tryptophan availability and/or noradrenaline release (McLeod & Golden 2000). Chromium has also been shown to lower the Cortisol response to challenge with 5-hydroxy-L-tryptophan (5-HTP) and decrease the sensitivity of 5-HT2A receptors (Attenburrow et al 2002).
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