Clinical trials using l-carnitine (1 g/day orally) found that it may be used successfully to prevent cardiac complications during IL-2 immunotherapy in cancer patients with clinically relevant cardiac disorders (Lissoni et al 1993). Thus a beneficial interaction is possible under professional supervision.
Research into the use of l-carnitine 4 g/day for 7 days showed a reduction in fatigue resulting from treatment with cisplatin (Graziano et al 2002) — beneficial interaction is possible under professional supervision.
HIV DRUGS (ZIDOVUDINE)
In vitro studies indicate prevention of muscle damage due to carnitine depletion (Dalakas et al 1994, Moretti et al 2002, Semino-Mora et al 1994). Patients with HIV infection undergoing highly active antiretroviral therapy can be carnitine deficient and supplementation of l-carnitine has been proposed to 'increase the number of CD4 cells and reduce lymphocyte apoptosis; improve symptoms of polyneuropathy; prevent cardiovascular damage from wasting and diarrhoea syndromes; decrease serum levels of triglycerides and TNF(alpha)' (llias et al 2004). Beneficial interaction is possible. Increased carnitine intake may be required with long-term therapy.
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