Inhibition Of Aldolase Reductase

In vitro studies show that licorice may suppress sorbitol accumulation in red blood cells by inhibiting aldolase reductase (Zhou & Zhang 1990). The ¡soliquiritigenin component appears to be responsible (Aida et al 1990a). This may have positive implications in diabetes.


Several flavonoid constituents in licorice (glabridin 60%, 4-O-methylglabridin 53% and glabrene 47%) inhibit serotonin reuptake in a dose-dependent manner, according to in vitro research. An antidepressant activity could theoretically result, although this remains to be tested clinically (Ofir et al 2003).

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