Inhibition Of Aldolase Reductase

In vitro studies show that licorice may suppress sorbitol accumulation in red blood cells by inhibiting aldolase reductase (Zhou & Zhang 1990). The ¡soliquiritigenin component appears to be responsible (Aida et al 1990a). This may have positive implications in diabetes.

ANTIDEPRESSANT (SEROTONIN REUPTAKE INHIBITION)

Several flavonoid constituents in licorice (glabridin 60%, 4-O-methylglabridin 53% and glabrene 47%) inhibit serotonin reuptake in a dose-dependent manner, according to in vitro research. An antidepressant activity could theoretically result, although this remains to be tested clinically (Ofir et al 2003).

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