Reduced drug and zinc absorption

Separate doses by at least 2 hours

Complex formation between zinc and tetracycline results In reduced absorption of both substances, with potential reduction In efficacy

Other antibiotics and antl-1 nfectlves (Trimethoprim [e.g. Trlprlm])


Monitor folate status with long-term or highdose therapy Beneficial Interaction possible

Increased folate Intake may be required with long-term or highdose therapy


Pyrimethamine (e.g. Daraprlm)


Reduced folate effects

Beneficial Interaction possible with follnlc acid

Impaired folate utilisation occurs with drug use — supplementation may be required

Chloroqulne (e.g. Chlorquln)

Vitamin E

Reduced drug effects


According to In vitro research, vitamin E Inhibits drug uptake In human cultured fibroblasts — clinical significance unknown



Potential outcome



Antituberculotics and Antileprotics

Cycloserine and isoniazid

Vitamin B6 (pyridoxine)

Reduced B6 levels

Beneficial interaction possible

Drug may induce pyridoxine deficiency. Increased intake may be required with long-term therapy


Vitamin B3 (niacin)

Reduced B3 levels

Beneficial interaction possible

Prolonged isoniazid therapy (the drug replaces niacinamide in NAD) may induce pellagra. Increased intake may be required with long-term therapy

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