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Zinc

Reduced drug and zinc absorption

Separate doses by at least 2 hours

Complex formation between zinc and qulnolones results In reduced absorption of both substances, with potential reduction In efficacy

Tetracycline antibiotics (e.g. minocycline [e.g.

Mlnomycln], doxycycllne)

Calcium

Reduced drug and calcium absorption

Separate doses by at least 2 hours

Tetracyclines form Insoluble complexes with calcium, thereby reducing Its absorption

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