Info

Vitamin B3 (niacin)

Increased drug requirement

Caution Monitor drug effectiveness

Niacin may affect glycaemlc control and Increase fasting blood glucose levels, so medication doses may need to be reviewed

Drug

Herb/Supplement

Potential outcome

Recommendation

Evidence/Comments

Metformin

Vitamin B12

Decreased vitamin B12 levels

Observe

Increased B12 intake may be required with long-term drug use

Thyroid hormones and antithyroid agents

Levothyroxine (e.g. Oroxine)

Calcium

Reduced drug absorption

Separate doses by 2-A hours

Calcium and thyroxine form an insoluble complex

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