Increased bruising and bleeding


Beneficial Interaction possible

Caution with high dose (>240 mg sallcln dally)

Theoretically may enhance anti-Inflammatory and antiplatelet effects. Although a clinical study found that consumption of sallcln 240 mg/day produced minimal effects on platelet aggregation, hlgherdoses may have a significant effect

Diclofenac sodium (topical)


Additive effects

Beneficial Interaction possible

In vitro studies have shown that the addition of glycyrrhlzln enhanced the topical absorption of diclofenac sodium — significance for licorice unknown

Sulfasalazine (e.g.



Reduced drug absorption

Separate doses by 2-3 hours

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