Info

St John's wort

Reduced drug effects

Avoid unless under medical supervision to alterdoses appropriately When St John's wort Is started or ceased, monitor serum levels and alter drug dosage as required

St John's wort may Increase drug metabolism, resulting In reduced drug efficacy

Carbamazeplne (e.g. Tegretol) NTI: signs of overdose Include CNS and respiratory depression, hypotension, vomiting, fluid retention

St Mary's thistle

Increased drug effects

Caution — monitor drug requirements

May reduce metabolism of drug resulting In Increased serum levels and adverse effects (difficult to evaluate evidence)

Drug

Herb/Supplement

Potential outcome

Recommendation

Evidence/Comments

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