Info

Zinc

Reduced drug absorption

Separate doses by 2 hours

L-Dopa can form an Insoluble complex with zinc

L-Dopa with ca rbldopa

Iron

Reduced drug effects

Separate doses by at least 2 hours

May reduce bioavailability of ca rbldopa and L-dopa

Drug

Herb/Supplement

Potential outcome

Recommendation

Evidence/Comments

Sedatives, hypnotics

CNS sedatives

Guarana

Reduced drug effects

Observe

Theoretically guarana may reduce the sedative effects of drug via Its CNS stimulation effects; however, an In vivo study found no Interaction with pentobarbital

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