St John's wort

Reduced drug effects

Avoid unless under medical supervision Monitor for signs of reduced drug effectiveness and adjust dose if necessary When St John's wort is started or ceased, monitor serum levels and alter drug dosage as required

St John's wort induces CYP enzymes and P-glycoprotein. A clinical trial shows that St John's wort significantly decreases serum levels of drug within 10 days of concomitant use



Dandelion leaf

Additive effects


Theoretically increased diuresis is possible — clinical significance is unknown

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