Info

Vitamin E

Reduced vitamin absorption

Separate doses by at least 4 hours and monitor vitamin status

Increased vitamin intake may be required with long-term therapy

Rifampicin

Vitamin D

Reduced vitamin D levels

Beneficial interaction possible

Increase vitamin D intake with long-term therapy

Antiviral agents

HIV drugs (e.g. zidovudine [AZT, e.g. Retrovi r])

Carnitine

Reduced carnitine levels

Beneficial interaction possible

In vitro studies indicate prevention of muscle damage due to carnitine depletion. Increased intake may be required with long-term therapy

HIV non-nucleoside transcriptase inhibitors

St John's wort

Reduced drug effects

Avoid

St John's wort increases drug metabolism, thereby reducing drug serum levels

HIV protease inhibitors

St John's wort

Reduced drug effects

Avoid

St John's wort increases drug metabolism, thereby reducing drug serum levels

Saquinavir

Garlic

Reduced drug effects

Avoid

A clinical study found that garlic reduces serum levels of saquinavir and therefore drug efficacy

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