Vitamin B2 (riboflavin)

Additive effects

Beneficial interaction possible

Vitamin B2 has demonstrated migraine prevention activity in several clinical studies

Clonidine (e.g. Cata près)

Coenzyme Q10

Reduced CoQ10 serum levels

Beneficial interaction possible

In vivo study indicates that clonidine reduces serum CoQ10 levels. Increased CoQ10 intake may be required with long-term therapy

Cardiac inotropic agents

Cardiac glycosides


Additive effects

Caution — monitor drug requirements (interaction may be beneficial)

Theoretical interaction, as in vitro and in vivo studies indicate that hawthorn has positive inotropic activity Small clinical study found interaction not clinically sig nficant when digoxin 0.25 mg taken with Hawthorn (WS1442) 450 mg twice daily



Potential outcome



Digoxin (e.g. Lanoxin) Adverse effects of high-dose digoxin include: nausea, vomiting, diarrhoea, confusion, fainting, palpitations, Irregular heart beat, visual dlstu rbances

Aloe vera

Increased drug toxicity

Avoid long-term use of high-dose preparations

Long-term oral use of aloe can deplete potassium levels and reduced potassium status lowers the threshold for drug toxicity

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