Vitamin B3 (niacin)

Additive effects

Beneficial Interaction possible — caution with sustained-release form

Several clinical trials confirm the cholesterol-lowering activity of niacin and the safety of niacin with statins, but the sustained-release form may be unsafe

Cholestyramine (e.g. Questran lite, colestipol [e.g. Colestid])

Fat-soluble vitamins (A, D, E, K, beta-carotene)

Reduced vitamin absorption

Separate doses by at least 4 hours and monitor vitamin status

Increased vitamin Intake may be required with long-term therapy

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