Important Cofactor

Vitamin B12 is essential for the normal function of all cells. It affects cell growth and replication, the metabolism of carbohydrates, lipids and protein and is involved in fatty acid and nucleic acid synthesis. It is also involved in the production of red blood cells in bone marrow, and activates folacin coenzymes for red blood cell production. Homocysteine reduction Methylcobalamin aids in the conversion of homocysteine to methionine by the action of methionine synthase, transferring a methyl group from methylfolate (folic acid).

After conversion from homocysteine, methionine is then converted to 5-adenosyl-L-methionine (SAMe), important for methylation reactions and protein synthesis. An increase in homocysteine levels and decrease in SAMe levels has been implicated in depression and may also contribute to the neurological symptoms seen in pernicious anaemia (IMG 2003).

Nervous system Vitamin B12 is involved in the synthesis of protein structures in the myelin sheath and nerve cells. As methylation is required for the production of myelin basic protein, a reduction in B12 and SAMe will result in demyelination of

peripheral nerves and the spinal column (subacute combined degeneration) (FAO/WHO 2002).

Immune system Vitamin B12 acts as an immunomodulator for cellular immunity (Tamura et al 1999).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

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