Both in vivo and in vitro studies provide evidence of immunostimulant effects, generally at doses beyond RDI levels. Vitamin C favourably modulates lymphocytes and phagocytes, regulates NK cells and can influence antibody and cytokine synthesis under certain situations (Hendler et al 2001). In high doses, it is a potent immunomodulator and is preferentially cytotoxic to neoplastic cells. Vitamin C enhances the activity of NK cells in vivo and also both B- and T-cell activity (Drisko et al 2003).

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