Hypocholesterolaemic effects of perilla have been demonstrated in vivo. Perilla oil Perilla 928

lowers cholesterol by suppressing hepatic HMG-CoA reductase activity (Du et al

2003). Peri I la oil also lowers plasma triacylg lycerol by suppressing fatty acid synthase (Kim et al 2004) and stimulating acyl-CoA oxidase (Kim & Choi 2005) in the liver.

Perilla oil mixed with borage and evening primrose oil has been shown to reduce cholesterol in older rats (Fukushima et al 2001).

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