A randomised, double-blind study of 40 hypercholesterolaemic subjects compared the effects of placebo, chromium polynicotinate (400^g/day), GSE (200 mg/day) or a combination of both. Over 2 months, the combination treatment decreased total cholesterol and LDL levels significantly but did not significantly alter homocysteine,

HDL or blood pressure among the four groups (Preuss et al 2000).

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