High Cholesterol

Probiotics modestly reduce cholesterol levels in healthy subjects and may have stronger effects in people with hyperlipidaemia.

A meta-analysis of six studies of a probiotic dairy product containing Enterococcus faecium found that the fermented yoghurt product produced a 4% decrease in total cholesterol and a 5% decrease in LDL-cholesterol (Agerholm-Larsen et al 2000).

© 2007 Elsevier Australia

In another study, 32 subjects with serum total cholesterol ranging from 5.7 to 7.25 mg/dL were randomly assigned to two treatments: (1) Intake of a low-fat drinking yoghurt prepared with two ordinary yoghurt starters (Streptococcus thermophilus and Lactobacillus delbrueckii subsp. Bulgaricus: placebo group); and (2) intake of a low-fat drinking yoghurt prepared with the two yoghurt starters plus Bifidobacterium longum strain BL1 (probiotic group). After intake for 4 weeks at 3 ■ 100 mL/day, reduction of serum total cholesterol was observed in approximately half of the probiotic group subjects; a particularly significant decrease in serum total cholesterol was found among subjects with moderate hypercholesterolemia (serum total cholesterol > 6.2 mg/dL). The serum lipid concentrations in the placebo group subjects were almost stable during the experimental periods (Xiao et al 2003).

A crossover study of 29 healthy women, aged 19-56 years, found that the long-term daily consumption of 300 g of two different types of yoghurt over a period of 21 weeks increased the serum concentration of HDL-cholesterol and led to the desired improvement of the LDL:HDL-cholesterol ratio. The normal yoghurt contained 3.5% fat and starter cultures of 5. thermophilus and L. lactis, whereas the probiotic yoghurt was enriched with L. acidophilus 145, B. longum 913 and 1% oligofructose. The mean serum concentration of total cholesterol and the LDL-cholesterol was not influenced by the normal yoghurt (P > 0.05). However, both the normal and the probiotic yoghurt increased the HDL concentration significantly, by 0.3 mmol/L (P= 0.002) and decreased the LDLHDL ratio from 3.24 to 2.48 (P= 0.001) (Kiessling et al 2002).

A recent controlled, randomised double-blind study of 36 heavy smokers found that 400 miyday of a rose hip drink containing L. plantarum 299v (5 ■ 107 colony-forming units/mL) led to a reduction in cardiovascular disease risk factors. Significant decreases in SBP, leptin, and fibrinogen (P < 0.001) were recorded in the experimental group. No such changes were observed in the control group. Decreases in F(2)-isoprostanes (markers of oxidative stress) (37%) and IL-6 (42%) were also noted in the experimental group in comparison with baseline. Monocytes isolated from subjects treated with L plantarum showed significantly reduced adhesion (P < 0.001) to endothelial cells (Naruszewicz et al 2002).

Lower Your Cholesterol In Just 33 Days

Lower Your Cholesterol In Just 33 Days

Discover secrets, myths, truths, lies and strategies for dealing effectively with cholesterol, now and forever! Uncover techniques, remedies and alternative for lowering your cholesterol quickly and significantly in just ONE MONTH! Find insights into the screenings, meanings and numbers involved in lowering cholesterol and the implications, consideration it has for your lifestyle and future!

Get My Free Ebook


Post a comment