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Animal studies have demonstrated that an intravenous extract of Siberian ginseng decreased thioacetamide-induced liver toxicity when given before and after thioacetamide administration (Shen et al 1991). More recently oral administration of aqueous extract and polysaccharide was found to attenuate fulminant hepatic failure induced by D-galactosamine/lipopolysaccharide in mice, reducing serum AST, ALT and TNF-alpha levels (Park et al 2004). The protective effect is thought to be due to the water-soluble polysaccharides.

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