Gastroprotective Effect

St Mary's thistle extract produces a dose-dependent anti-ulcerogenic activity against indomethacin-induced ulcers, which can be histologically confirmed, according to research with test animals (Khayyal et al 2001). This is associated with reduced acid output, increased mucin secretion, increased PGE2 release and decreased leukotriene release.

Experiments with the silymarin constituent group have found it to be effective in the prevention of gastric ulceration induced by cold-restraint stress in rats (Alarcon et al 1992) and post-ischaemic gastric mucosal injury (Alarcon et al 1995).

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