B group vitamins are often taken by the public to lessen the impact of 'stress' and provide an energy boost. In one study, thiamine 10 mg/day significantly increased appetite, energy intake, body weight, general wellbeing and decreased fatigue, compared with placebo in a group of 80 randomly chosen women from a population with known marginal deficiency (Smidt et al 1991). Thiamine supplementation also tended to reduce daytime sleep time, improve sleep patterns, and increase activity.

Several neuropathological reports have described brain lesions characteristic of Wernicke's encephalopathy in patients with AIDS. One study found a 23% prevalence of thiamine deficiency in AIDS patients with no history of alcohol abuse (Butterworth et al 1991).

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