A randomised, placebo-controlled study involving 72 patients with epilepsy who had received long-term phenytoin treatment alone or in combination with phénobarbital Vitamin B1 1207

found that administration of thiamine (50 mg/day) over 6 months improved

neuropsychological functions in both verbal and non-verbal IQ testing (Botez et al 1993). This study also found both folate supplementation and placebo ineffective.

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