Enhance Wound Healing

Pantothenic acid has been both used as an oral supplement and applied topically in a cream base to enhance wound healing and it has been shown to accelerate closure of wounds and increase strength of scar tissue in experimental animals (Plesofsky 2002, Vaxman et al 1990). Although these results are encouraging, there has been little investigation in humans. One double-blind study testing the effects of vitamin C (1000 mg) and pantothenic acid (200 mg) supplements over a 21 -day period showed no significant alteration to wound healing with this treatment regimen (Vaxman et al 1995).

Topical use Bepanthen is a well-known dermatological preparation containing dexpanthenol, an alcoholic analogue of pantothenic acid. It has been investigated in numerous studies and found to act like a moisturiser, activate fibroblast proliferation, accelerate re-epithelialisation in wound healing, have anti-inflammatory activity against UV-induced erythema and reduce itch (Ebner et al 2002). Under double-blind study conditions, epidermal wounds treated with dexpanthenol emulsion showed a reduction in erythema, and more elastic and solid tissue regeneration. Another randomised, prospective, double-blind, placebo-controlled study published in 2003 investigated the efficacy of topical dexpanthenol as a skin protectant against irritation. The study involved 25 healthy volunteers who were treated with a topical preparation containing 5% dexpanthenol or placebo and then exposed to sodium lauryl sulphate 2% twice daily over 26 days. Treatment with topical dexpanthenol provided protection against skin irritation whereas a statistically significant deterioration was observed in the placebo group (Biro et al 2003).

Although commonly used in radiotherapy departments to ameliorate acute radiotherapy skin reactions, a prospective study of 86 patients undergoing radiotherapy showed that topical use of Bepanthen did not improve skin reactions under these conditions (Lokkevik et al 1996). Similarly, negative results were also obtained in an animal study by Dorr et al (2005). Vitamin B5 - Pantothenic acid 1242

Nasal spray A RCT of 48 outpatients diagnosed with rhinitis sicca anterior found that dexpanthenol nasal spray is an effective symptomatic treatment for this condition (Kehrl & Sonnemann 1998). Two years later, another RCT compared the effects of xylometazoline-dexpanthenol nasal spray versus xylometazoline nasal spray over a 2-week period in 61 patients with rhinitis after nasal surgery (Kehrl & Sonnemann 2000) and showed that the combination of xylometazoline-dexpanthenol nasal spray was significantly superior to the other treatment and well tolerated.

More recent studies support this emerging trend and point towards a reduction in ciliary and cytotoxic effects from the nasal decongestants when 5% dexpanthenol is concurrently administered (Klocker et al 2003).

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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