Endothelial Function

A randomised study involving 40 dyslipidaemic patients with type 2 diabetes mellitus found that oral CoQ10 (200 mg daily) taken over 12 weeks improved the endothelial function of conduit arteries of the peripheral circulation (Watts et al 2002). Another study of 80 subjects using the same dose for the same treatment period failed to improve endothelial forearm vasodilator function when given alone, although when combined with fenofibrate, the effectiveness was significant (Playford et al 2003). Both research groups suggested that the effect may be due to an increase in the bioactivity of and/or responses to endothelium-derived relaxing factors, including nitric oxide.

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