Although St Mary's thistle has been most commonly investigated for its effects as a hepatoprotective agent, it is commonly used to treat dyspeptic complaints, such as loss of appetite, poor digestion and upper gastrointestinal discomfort. Animal studies have identified a dose-dependent increase in bile flow and bile salt secretion for Silymarin, achieved by stimulating the synthesis of bile salts (Crocenzi et al 2000).

Commission E approves the use of crude milk thistle preparations for dyspeptic st Ma 's thistle 1043

complaints (Blumenthal et al 2000). ^ arystlste

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