Drugs Metabolised Chiefly By Cyp1a And Cyp2d6

Mixed reports exist as to whether ginseng may act as an inhibitor of cytochrome CYP1A (Gurley et al 2005, Lee et al 2002b, Yu etal 2005) or CYP2D6 (Gurley et al 2005) and if so whether the effect is likely to be clinically significant. Observe for increased drug bioavailability and clinical effects. Ginseng—Korean 565

^pv NIFEDIPINE

Vi/ Ginseng increased the mean plasma concentration of the calcium channel blocker nifedipine by 53% at 30 minutes in an open trial of 22 healthy subjects. Effects at other time points were not reported (Smith et al 2001). Caution.

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