Dermatological Uses

Vitamin C is used as an oral supplement or topical application in a number of dermatological conditions.

Wound healing Vitamin C is important for effective wound healing, as deficiency contributes to fragile granulation tissue and therefore impairs the wound-healing process (Russell 2001).

In vitro studies with skin graft samples have demonstrated that vitamin C extends cellular viability, promotes formation of epidermal barrier and promotes engraftment (Boyce et a I 2002). In this way, vitamin C is used to enhance wound healing before surgery has commenced.

Numerous case reports of surgical and dental patients generally suggest a use for vitamin C supplementation in doses beyond RDI as a means of enhancing the rate of wound healing (Ringsdorf & Cheraskin 1982). One early double-blind study found that vitamin C (500 mg twice daily) resulted in a significant mean reduction in pressure sore area of 84% after 1 month compared with 43% in the placebo group (Taylor et al 1974). The mean rates of healing were 2.47 cm2 for vitamin C and 1.45 cm2 for placebo.

Photo-aged skin Two double-blind studies investigating the effects of topical preparations of vitamin C on photo-damaged skin have demonstrated good results after 3 months' use (Fitzpatrick & Rostan 2002, Humbert et al 2003). One study tested a topical application of 5% vitamin C in a cream base, whereas the other used a newly formulated vitamin C complex having 10% ascorbic acid (water soluble) and 7% tetrahexyldecyl ascorbate (lipid soluble) in an anhydrous polysilicone gel base. Prevention of sunburn One controlled study found oral vitamin C (2000 mg/day) in combination with vitamin E (1000 lU/day) had a protective effect against sunburn after 8 days' treatment in human subjects (Eberlein-Konig et al 1998).

Similar results have been obtained for topical vitamin C preparations in several animal models (Darr et al 1992, 1996, Lin et al 2003) and a small human study (Keller & Fenske 1998). The latter study found that application of an aqueous 10% l-ascorbic acid solution produced a significant reduction in the minimal erythema dose and a less intense erythematous response than controls after UVB radiation.

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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