Twenty patients with unipolar depression had an improved response to antidepressant medication when taken with zinc aspartate supplements (equivalent to 25 mg elemental daily), according to a small, double-blind pilot study (Nowak et al 2003). Significantly greater reductions in Hamilton Depression Rating Scale scores were achieved with zinc treatment compared to placebo by the 6th week and maintained until the end of the 12-week study.


Although reduced zinc status has been associated with chronic diarrhoea and Crohn's disease (Sturnlolo et al 1980), the results from a small open study demonstrated that oral zinc sulfate (110 mg three times daily) resolved intestinal permeability problems in people with increased permeability and decreases relapse rates (Sturniolo et al 2001).

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