Cystic Fibrosis

Cystic fibrosis (CF) is characterised by exocrine pancreatic insufficiency and reduced absorption of fat-soluble vitamins, as well as chronic lung inflammation and an associated increased oxygen free radical generation. Patients with CF have been found to have lower levels of beta-carotene and it has been suggested that they would benefit from beta-carotene supplementation (Cobanoglu et al 2002, Walkowiak et al 2004). This suggestion is supported by a study of 52 patients with CF that found a statistically significant correlation between serum beta-carotene and the clinical course of the disease as indicated by faecal elastase-1 and FEV-| (Walkowiak et al 2004), together with a study showing that the plasma levels of beta-carotene and vitamin E increased and the plasma levels of TNF-alpha and malondialdehyde decreased after 6 months of beta-carotene supplementation (Cobanoglu et al 2002). This is further supported by a RCT of 24 CF patients supplemented with up to 50 mg/day beta-carotene for 12 weeks and 10 mg/day beta-carotene for a further 12 weeks, which found a significant decrease in oxidative stress, correction of total antioxidative capacity and improved pulmonary response to treatment in the supplemented group (Rust et al 2000).

Was this article helpful?

0 0
Lower Your Cholesterol In Just 33 Days

Lower Your Cholesterol In Just 33 Days

Discover secrets, myths, truths, lies and strategies for dealing effectively with cholesterol, now and forever! Uncover techniques, remedies and alternative for lowering your cholesterol quickly and significantly in just ONE MONTH! Find insights into the screenings, meanings and numbers involved in lowering cholesterol and the implications, consideration it has for your lifestyle and future!

Get My Free Ebook

Post a comment