Contraindications And Precautions

• Malignant melanoma: a theoretical concern exists that tyrosine supplementation may promote the division of cancer cells (McArdle et al 2001). Tyrosine is contraindicated until safety is established.

• Manic conditions: due to the theoretical possibility that tyrosine may significantly increase neurotransmitter synthesis, close medical supervision is required (Cass & Holford 2001).

• Hyperthyroidism and Graves' disease: theoretically tyrosine may aggravate these conditions as it is a precursor to thyroxine (van Spronsen et al 2001).

• Alkaptonuria and tyrosinaemia (inborn errors of tyrosine metabolism).

• Hypertension: use tyrosine with caution at high dose.

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