Coenzyme

Vitamin B6 is an important coenzyme in the biosynthesis of the neurotransmitters GABA, dopamine and serotonin (Gerster 1996). It is also involved in protein metabolism, haemoglobin synthesis, gluconeogenesis, lipid metabolism, niacin formation, immune system processes, nucleic acid synthesis and hormone modulation (Bratman & Kroll 2000, Wardlaw et al 1997).

Homocysteine Homocysteine is formed from the essential amino acid methionine and about 50% is then remethylated to methionine via steps that require folic acid and vitamin B12. Vitamin B6 is required for another metabolic pathway and is a cofactor for cystathionine beta-synthase, which mediates the transformation of homocysteine to cystathionine (Wilcken & Wilcken 1998). Serotonin Pyridoxine is required for the synthesis of many neurotransmitters, including serotonin. It is a cofactor for the enzyme 5-hydroxytryptophan decarboxylase, which is involved in one of the steps that converts tryptophan to serotonin (Pelton et al 1999). As such, deficiency states are associated with alterations to mood and other psychological disturbances.

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