Clinical Use

The conditions for which folate is indicated as a potential treatment are primarily due to an existing deficiency, through either primary or secondary pathways. Research has focused particularly on those conditions in which folate deficiency is a consequence of medication use and benefits of improved folate status. PREVENTION AND TREATMENT OF DEFICIENCY

Commonly, folic acid supplements are used to correct identifiable deficiency states, such as macrocytic anaemia, or given as preventative treatment to those patients at risk of deficiency, such as in malabsorption syndromes or taking long-term folate antagonist medication. Increased oral intake of folate has been found to be effective even in cases of malabsorption due to the passive diffusion evident with pharmacological doses (Carmel 2006).

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