Clinical Use

The form most commonly used at the moment is the perilla seed defatted extract; however, this review will also include information regarding other forms. CANCER

Phase I clinical trials have shown a favourable toxicity profile and preliminary data have indicated some chemotherapeutic efficacy in advanced cancers. However, perillyl alcohol (1200 mg/m2 four times daily) failed to extend the time-to-progression in three phase II studies in patients with advanced ovarian carcinoma (Bailey et al 2002), prostate cancer (Liu et al 2003) and colorectal cancer. All trials were very small and had to contend with high drop-out rates due to intolerability of the medicine. Despite encouraging preclinical results, perilla does not appear to be an effective treatment for advanced cancer.

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