Evidence to support the herb's use in prostatitis is scarce. However, in April 2003 positive findings from a preliminary study using Permixon to treat symptoms of chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) were presented at the annual meeting of the American Urological Association (Anon 2003). The RCT involving 61 patients with category IIIB CP/CPPS found that 75% receiving active treatment experienced at least mild improvement in symptoms, compared with 20% of the control group. Furthermore, 55% of patients receiving Permixon reported moderate or marked improvement, compared with 16% of the control group. In contrast, results from a 2004 prospective, randomised, open-label study failed to find benefits for saw palmetto (325 mg daily) in men diagnosed with category III CP/CPPS (Kaplan et al 2004). After 1 year, the mean total National Institutes of Health Chronic Prostatitis Symptom Index score decreased from 24.7 to 24.6 (P = 0.41) and no benefits were seen for QOL or pain with saw palmetto treatment.
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