Choleretic activity has been demonstrated for peppermint tea, flavonoids and the essential oil in dogs and rats (ESCOP 1997). Hydrophilic compounds may contribute to the gastrointestinal effects, with aqueous extracts from peppermint leaves having anti-ulcerogenic and choleretic effects (Grigoleit & Grigoleit 2005c, Van Rensen

2004). Peppermint oil has been shown to have a relaxing effect on the gall bladder and small intestine, producing complete inhibition of gall-bladder emptying and prolonged orocaecal transit time comparable to that produced by n-butylscopolamine (Goerg & Spilker 2003).

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