Chemical Components

Vitamin B12 is the largest of the B vitamins and is a complex structure containing a central cobalt atom. There are five forms of B12: cyanocobalamin (a synthetic form that has a cyanide attached to the cobalt), hydroxycobalamin (hydroxyl group attached to the cobalt; it is produced for parenteral administration), aquacobalamin (water group bound to the cobalt) and the coenzymatically active forms (methylcobalamin and 5-deoxyadenosylcobalamin), in which a methyl group or a 5-deoxyadenosyl group is bound to the cobalt atom (FAO/WHO 2002, Freeman et al 1999).

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