Cardioprotective Effects

Considering that GSE demonstrates antioxidant, antiplatelet and anti-inflammatory actions, it may have a role in the prevention of cardiovascular disease. A number of researchers have investigated this issue further, mainly using animal models. One series of studies was conducted by Bagchi et al (2003) using a natural, standardised, water-ethanol extract made from California red grapeseeds, which contained Grapeseed extract 646

approximately 75-80% oligomeric PCs and 3-5% monomeric PCs. According to in © 2007 Elsevier Australia

vivo research, treatment with GSE provided resistance to myocardial ischaemia-reperfusion injury, better post-ischaemic ventricular recovery and reduced incidence of reperfusion-induced ventricular fibrillation and ventricular tachycardia, as compared with corresponding control animals. Another study using a hamster atherosclerosis model found that 50 and 100 mg GSE/kg body weight led to a 49% and 63% reduction in foam cells respectively. Additionally, cholesterol and triglyceride lowering activity has been reported (Yu et al 2002).

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