Brain

Evidence is emerging about the specific role of vitamin D in the brain. Information to date implicates 1,25(OH)2D in the biosynthesis of neurotrophic factors, contribution to brain detoxification pathways with increased glutathione and reduced NO, neuroprotective effects, induction of glioma cell death and involvement in neurotransmitter synthesis including acetylcholine and the catecholamines (Garcion et al 2002). Preliminary studies in rats have demonstrated an anti-epileptic action (Kalueff &Tuohimaa 2005). There are tentative links being made between the aetiology/pathophysiology of Parkinson's disease and poor vitamin D status (Johnson 2001, Kim etal 2005).

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