Bladder Effects

Pygeum protects the bladder from contractile dysfunction induced by ischaemia and reperfusion according to in vivo studies. Studies with rabbit models have shown that pretreatment can prevent the bladder from developing contractile and biochemical dysfunctions induced by partial outlet obstruction, possibly by protecting the bladder from ischaemic injury (Levin et al 2005). It has also been shown that treatment can reverse these dysfunctions when started 2 weeks post obstruction. Past studies have used very high doses to achieve these results; however, the recent study using a clinically relevant dose found treatment was still effective (Levin et al 2005).

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