Benign Prostatic Hypertrophy

Isoflavone-containing supplements are widely used in patients with BPH. Recently, an in vivo study using mice showed that red clover-derived isoflavones have a significant effect on prostatic growth, and are capable of reducing the tendency to enlarged non-malignant prostate, by acting as anti-androgenic agents rather than weak oestrogenic substances (Jarred et al 2003). A case series (n = 29) presented at the Endocrine Society's 82nd Annual Meeting in 2000 suggested that 3 months of Red clover 998

treatment with 1 or 2 tablets of Trinovin (standardised to 40 mg red clover

isoflavones per tablet) significantly decreased nocturia frequency, the International Prostate Symptom Score, increased urinary flow rates and QOL score. The PSA values and prostate size did not alter from baseline (Ulbricht & Basch 2005).

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