Antiulcer Effects

Licorice demonstrates the ability to promote mucosal repair and reduce symptoms of active ulcer (Larkworthy & Holgate 1975).

The anti-ulcer effects of licorice are due to inhibition of 1 5-hydroxyprostaglandin dehydrogenase, (which converts PGE2 and F2a|pha to their inactive forms) and delta 13-PG reductase. Licorice-derived compounds therefore increase the local concentration of PGs that promote mucus secretion and cell proliferation in the stomach, leading to healing of ulcers (Baker 1994).

Anti-inflammatory activity (as described above) further contributes to the herb's symptom-relieving action.

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