It has been suggested that theobromine, a methylxanthine derivative present in Cocoa 288

cocoa, may form the basis for a new class of antitussive drugs, as it has been shown

to effectively inhibit citric acid-induced cough in guinea-pigs in vivo, as well as suppress capsaicin-induced cough in a human double-blind trial. The observation that theobromine inhibits capsaicin-induced sensory nerve depolarisation of the guinea-pig and human vagus nerve suggests that its antitussive action may be mediated peripherally through an inhibitory effect on afferent nerve activation (Usmani et al 2005).

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