Antiplatelet And Antithrombotic Activity

Andrographolide inhibits platelet-activating-factor-induced human blood platelet aggregation in a dose-dependent manner (Amroyan et al 1999). Results from in vivo studies suggest that andrographis prevents the formation of thrombi and reduces the size of myocardial ischaemia by promoting synthesis of prostaglandin l2, inhibiting production of thromboxane A2, stimulating synthesis of cyclic AMP in platelets, and inhibiting platelet aggregation (Zhao & Fang 1990, 1991). Clinical research in humans has confirmed the observed antiplatelet effect (Zhang et al 1994).

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