Sage extracts have been shown to have strong anti-oxidant activity (Matsingou et al 2003, Pizzale et al 2002), with labiatic acid and carnosic acid reported to be the active compounds (Perry et al 2003). According to in vivo studies with animal models, ingestion of sage infusion improves the liver's antioxidant status (Lima et al 2005) and protects against azathioprine-induced toxicity (Amin & Hamza 2005). However, sage essential oil did not show protective effects against toxicity from an oxidative compound in isolated rat hepatocytes (Lima et al 2004).

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