In vitro tests have identified antioxidant activity (Ohsugi et al 1999). More specifically, seven lignans isolated from schisandra have demonstrated stronger antioxidant activity than vitamin E at the same concentrations, with schisanhenol exhibiting the strongest effects (Lu & Liu 1992). An extract of schisandra and the isolated constituent schisandrin B have both demonstrated the ability to significantly decrease ALT and increase glutathione levels in CCL4 damaged liver in vivo (Chiu et al 2002). It appears that several constituents also have indirect antioxidant activity and can increase hepatic and myocardial glutathione levels (Yim & Ko 1999).
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