Sage is reported to have antimicrobial activity attributed to the thujone, thymol and eugenol content of the volatile oil (Shapiro 1994), as well as its rosmarinic acid content (Petersen & Simmonds 2003). The phenolic acids, salvins and monomethyl ethers have also been attributed with antimicrobial activity. Overall, activity has been reported in vitro against Staphylococcus aureus, Escherichia coli, Salmonella spp., Shigella sonnei, Klebsiella ozanae, Bacillus subtllls and various fungi including Candida albicans (Newell et al 1996). Phenolic extracts have also shown antibacterial sage 1013

activity against Enterococcus (Feres et al 2005). Sage had some in vitro antimicrobial

effects on saliva samples from periodontal^ healthy and diseased subjects, although it had less activity than clove or propolis (Feres et al 2005). Sage essential oil has been shown to have effective inhibitory activity against microorganisms, such as Klebsiella spp., Enterobacterspp., E. coll, Proteus mlrabilis and Morganella morganli, isolated from urinary tract infection (Santos Pereira et al 2004). There are also reports that sage may also be fungistatic and virustatic (Eidi et al 2005).

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