Pretreatment with baical root extract has been shown to decrease cisplatin-induced pica in rats (animal models use the level of kaolin [a type of clay] intake as a measure of the intensity of nausea). This suggests that baical may help to reduce cisplatin-induced nausea and emesis during cancer therapy (Aung et al 2003, Mehendale et al 2004, Wu et al 1995), although clinical testing is required to confirm significance.

In a recent in vivo trial, 5. baicalensis was found to significantly attenuate ritonavir-induced pica, and demonstrate possible efficacy for the management of ritonavir-induced nausea in HIV treatment (Aung et al 2005).

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