Antidepressant Activity

Several different constituents within perilla leaf have demonstrated effects on behaviour in vivo, most notably antidepressant effects.

Rosmarinic acid and caffeic acid have demonstrated antidepressant activity in a forced swimming test in mice. The activity is thought to be via some mechanism other than the inhibition of monoamine transporters and monoamine oxidase (Takeda et al 2002a). Apigenin from perilla significantly reduced immobility in a forced swimming test in mice, an effect mediated by dopaminergic mechanisms (Nakazawa et al 2003).

Rosmarinic acid and caffeic acid have been shown to decrease the duration of the defensive freezing behaviour caused by fear and stress in animals (Takeda et al Perilla 929

2002b).

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