Three recent studies have identified an anti-arrhythmic effect mediated by ALA (Albert et al 2005, Ander et al 2004, Christensen et al 2005) although one meta-analysis concluded otherwise (Mathan et al 2005). Although the majority of research has been conducted in animals, one of the most interesting human trials involved 106 women with a mean age of 59.5 years referred for coronary angiography due to suspected coronary artery disease. Following adipose sampling for ALA levels and monitoring of 24-hour heart rate variability (HRV), it was concluded that a positive and independent association was present between ALA in adipose tissue and HRV, which was even stronger in smokers (Christensen et al 2005).

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